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Atul Butte, MD, PhD
Principal Investigator, California Initiative to Advance Precision Medicine
Atul Butte is the director of the Institute of Computational Health Sciences (ICHS) at the UC San Francisco and is a Professor of Pediatrics.
He is also the Executive Director of Clinical Informatics for UC Health Sciences and Services, a position in which he will assist in the ongoing development and implementation of a UC-wide data warehouse and analytic platform.
Butte trained in Computer Science at Brown University, worked as a software engineer at Apple and Microsoft. He received his MD at Brown University, trained in Pediatrics and Pediatric Endocrinology at Children's Hospital Boston, then received his PhD from Harvard Medical School and MIT. Dr. Butte has authored nearly 200 publications, with research repeatedly featured in Wired Magazine, the New York Times, and the Wall Street Journal. Butte is also the principal investigator of ImmPort, an archival and dissemination repository for clinical and molecular datasets funded by the National Institute of Allergy and Infectious Diseases.
In 2013, Butte was recognized by the White House as an Open Science Champion of Change for promoting science through publicly available data. Other recent awards include the 2015 induction into the National Academy of Medicine, the 2014 E. Mead Johnson Award for Research in Pediatrics, the 2013 induction into the American Society for Clinical Investigation, the 2012 FierceBiotech IT “Top 10 Biotech Techies”, and the 2011 National Human Genome Research Institute Genomic Advance of the Month. Butte is also a founder of three investor-backed data-driven companies: Personalis, providing clinical interpretation of whole genome sequences, Carmenta, discovering diagnostics for pregnancy complications, and NuMedii, finding new uses for drugs through open molecular data.
Elizabeth Baca, MD, MPA
Senior Health Advisor, Governor’s Office of Planning and Research
Elizabeth Baca serves as the Senior Health Advisor in the Governor’s Office of Planning and Research (OPR) and provides vision, leadership and oversight of CIAPM. She is engaged in innovation in the public sector to foster health through multiple projects including public-private partnerships, big data, and healthy planning. She is passionate about innovations to foster total health and well-being. Baca is skilled at using collaborative approaches to accomplish cross-sector work. Her portfolio involves working across agencies and departments in California as well as with many foundation, non-profit, for-profit groups, and entrepreneurs.
Previously, Baca served on the General Pediatric Faculty at Stanford Medical School and directed the Community Pediatric and Child Advocacy Rotation. In addition to teaching medical students and residents about the social, economic, and environmental factors that affect health, Baca was the lead faculty mentor on several projects to increase access to healthy foods, reduce environmental triggers of asthma, increase physical activity opportunities, and improve the built environment.
Baca studied health policy at Universidad Simon Bolivar in Venezuela. She completed her Masters in Public Administration at Harvard Kennedy School of Government and her medical degree at Harvard Medical School. Baca completed her pediatric residency in the Pediatric Leadership for the Underserved (PLUS) program at UC San Francisco.
Theresa O’Brien, PhD
Associate Chancellor, UC San Francisco
Theresa O'Brien was appointed Associate Chancellor at UC San Francisco in September 2014, having served as Interim Assistant Chancellor for the University and Associate Dean for Research Strategy in the School of Medicine. She serves as an advisor to and designate of the Chancellor, leading key initiatives in support of UCSF’s operational and strategic priorities. O’Brien is accountable for a wide range of Chancellor Office activities related to UCSF governance structure, strategic planning, the Chancellor’s Executive Cabinet (CEC), and emergent priority issues on a day-to-day basis. In all aspects of her work, she partners closely with fellow CEC members and internal and external stakeholders to further UCSF’s mission.
The advancement of precision medicine is one of the Chancellor’s priorities for UCSF. O’Brien led UCSF’s partnership efforts with the Governor’s Office and UC Health to establish the CIAPM, and she serves as the lead for aligning the goals of UCSF, the Governor’s Office and CIAPM.
O’Brien is also an Assistant Adjunct Professor of Cellular and Molecular Pharmacology. Her research and teaching interests primarily focus on career and professional development for graduate students and postdoctoral scholars at UCSF. She directs the Graduate Student Internships for Career Exploration (GSICE) program, which provides career path education, career planning, and internship opportunities for UCSF’s basic and biomedical PhD students in fields outside of academic research. O’Brien is co-PI on a grant from the NIH to provide better resources for PhD students and postdocs to explore career options and better support faculty mentors through the Motivating INformed Decisions (MIND) program.
Theresa is a graduate of UCSF's Tetrad Graduate Program and completed her doctoral work in biochemistry under the guidance of Jim McKerrow, MD, PhD. After graduation, she worked as an Industry Contracts Officer at UCSF, negotiating industry sponsored research agreements. A Northern California native, she graduated summa cum laude with a BA in Biology from Williams College in Williamstown, Mass.
India Hook-Barnard, PhD
Director of Research Strategy; Associate Director, Precision Medicine, UC San Francisco
India Hook-Barnard is Director of Research Strategy and Associate Director, Precision Medicine, at UCSF. She serves as director of the UCSF Precision Medicine Platform Committee, which aims to conceptualize and build precision medicine as a central overarching institutional vision at UCSF. She helped launch and continues to partner with CIAPM to advance the initiative.
In the UCSF Office of Research and the School of Medicine Dean’s Office, she works with scientific experts and leaders from across academia, industry and government sectors to identify and frame scientific opportunities, technical feasibility, and organizational challenges. She develops and supports research training programs, efforts to secure major research and infrastructure funding, and provides advice, consultation and analysis on scientific initiatives.
Hook-Barnard’s primary interests are in areas of emerging science, technology and medicine, from fundamental research to translational application and clinical practice, including issues of policy, regulation, ethical and societal concerns, and workforce. From 2008 to 2015, she worked as a senior program officer with the National Academy of Sciences (NAS) and the Institute of Medicine (IOM). At the NAS and IOM, she developed and administered a variety of programs, working with academic faculty, scientists, engineers, clinicians, business leaders and policy experts. She served as the study director for six National Academies reports, including Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease (2011), and Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk (2015.)
Hook-Barnard was a postdoctoral research fellow at the National Institutes of Health. She earned her PhD in Microbiology-Medicine from the Department of Molecular Microbiology and Immunology at the University of Missouri.
Keith Yamamoto, PhD
Vice Chancellor for Science Policy and Strategy, UC San Francisco
Keith Yamamoto is UCSF vice chancellor for science policy and strategy, vice dean for research in the school of medicine, and professor of cellular and molecular pharmacology at UCSF. He is a leading researcher investigating transcriptional regulation by nuclear receptors, which mediate the actions of essential hormones and cellular signals; he uses mechanistic and systems approaches to pursue these problems in pure molecules, cells and whole organisms. He has led or served on numerous national committees focused on public and scientific policy, public understanding and support of biological research, and science education; he chairs the Coalition for the Life Sciences, and sits on the National Academy of Medicine Council and the National Academy of Sciences Division of Earth and Life Studies Advisory Committee. As chair of the National Academy of Sciences' (NAS) Board on Life Sciences, he created the study committee that produced “Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease”, the report that enunciated the precision medicine concept, and he has helped to lead efforts in the White House, in Congress, in Sacramento and at UCSF to implement it. This includes serving as chair of the UCSF Precision Medicine Platform Committee, and continued leadership and support of CIAPM.
Yamamoto has chaired or served on many committees that oversee training and the biomedical workforce, research funding, and the process of peer review and the policies that govern it at NIH. He is a member of the advisory board for Lawrence Berkeley National Laboratory and the board of directors of Research!America. He was elected to the NAS, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Academy of Microbiology, and is a fellow of the American Association for the Advancement of Science.
Uta Grieshammer, PhD
Program Director, California Initiative to Advance Precision Medicine
As the program director for CIAPM, Uta Grieshammer is responsible for overseeing the execution of demonstration projects, organizing workshops and other convening activities, and developing an inventory of precision medicine assets in California. She works with Atul Butte, the principal investigator for CIAPM, and with leadership from UC San Francisco, the Governor’s Office and Office of Planning and Research, and the UC Office of the President to ensure the timely and successful completion of the scope of work for CIAPM.
Grieshammer received her PhD in Biochemistry from Boston University. She is a developmental biologist with expertise in stem cell biology and the mechanisms of organ formation. Prior to joining CIAPM, she served close to eight years as a Science Officer at the California Institute for Regenerative Medicine, the state’s stem cell agency, managing a portfolio of stem cell grants, developing requests for applications and communicating stem cell concepts and clinical advances to diverse audiences.