Early Prostate Cancer: Predicting Treatment Response

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Principal Investigator

Sheldon Greenfield, MD, Executive Co-Director, Health Policy Research Institute, School of Medicine, UC Irvine 

Project Description

Prostate cancer is the most common cancer in men, with over 200,000 new cases diagnosed each year in the U.S. It is the second leading cause of cancer death in men, and affects roughly 1 in 7 men over their lifetime.

An important goal toward achieving better outcomes is to be able to predict, prior to treatment, which therapy will work best for each patient.

This proposal focuses on improving these predictions for patients with early stage prostate cancer, based on diverse information, including (i) detailed patient characteristics and patient reported outcomes such as socio-demographic information, health status and disease management burden, (ii) traditional prostate cancer severity indicators and (iii) an already established genomic test that measures the probability of cancer spread after surgery.

Another important objective of this project is to understand the validity of these predictive measures in an ethnically diverse patient population.

The final combined prediction model will aid doctors and patients in personalizing prostate cancer treatment decisions to maximize effectiveness, and choose the treatment optimal for individual patients.

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Project Partners

  • UC Los Angeles
  • Veterans Affairs Long Beach Healthcare System
  • Veterans Affairs Greater Los Angeles Healthcare Systems
  • Cedars-Sinai Medical Center